AGN 194310 I-3 Formula: C21H21ClF2O4S

Formula: C21H21ClF2O4S

appears to have the potential to exert marked anxiolytic and antidepressant activity in humans

It up regulates PDX1 expression in both primary human islets and ductal cells

which are not observed in PI3Kδ mutant (p110δD910A) cells

Apilimod inhibits IL-12 and IL-23 production - cytokines that are involved in autoimmune diseases - through the prevention of nuclear translocation of c-Rel

AGN 194310 I-3 Formula: C21H21ClF2O4SAGN 194310, also known as VTP 194310, is a pan antagonist of retinoic acid receptors (RARs) with Kd values of 3nM, 2nM and 5nM for RAR , RAR and RAR, respectively. AGN 194310 has been reported to bind to RARs with equal and high Kd values of 3, 2 and 5nM for RAR , RAR and RAR, respectively, by in vitro binding experiments. In addition, AGN 194310 has been revealed to potently inhibit the colony formation by ITS+ grown cell lines with IC50 values of 16