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ALW-II-41-27 - CAS# 1186206-79-0 Catalog No.:M10038-10 CC1C2=C(SC=1C(=O)NCCCCCNC1=CC=CC3=C1C(=O)N(C1CCC(=O)NC1=O)C3=O)N1C(=NN=C1C)[C@H](CC(=O)OC)N=C2C1C=CC(Cl)=CC=1
ALW-II-41-27 - CAS# 1186206-79-0 Catalog No.:M10038-10 CC1C2=C(SC=1C(=O)NCCCCCNC1=CC=CC3=C1C(=O)N(C1CCC(=O)NC1=O)C3=O)N1C(=NN=C1C)[C@H](CC(=O)OC)N=C2C1C=CC(Cl)=CC=1
ALW-II-41-27 - CAS# 1186206-79-0 Catalog No.:M10038-10 CC1C2=C(SC=1C(=O)NCCCCCNC1=CC=CC3=C1C(=O)N(C1CCC(=O)NC1=O)C3=O)N1C(=NN=C1C)[C@H](CC(=O)OC)N=C2C1C=CC(Cl)=CC=1
ALW-II-41-27 - CAS# 1186206-79-0 Catalog No.:M10038-10 CC1C2=C(SC=1C(=O)NCCCCCNC1=CC=CC3=C1C(=O)N(C1CCC(=O)NC1=O)C3=O)N1C(=NN=C1C)[C@H](CC(=O)OC)N=C2C1C=CC(Cl)=CC=1

ALW-II-41-27 - CAS# 1186206-79-0 Catalog No.:M10038-10 CC1C2=C(SC=1C(=O)NCCCCCNC1=CC=CC3=C1C(=O)N(C1CCC(=O)NC1=O)C3=O)N1C(=NN=C1C)[C@H](CC(=O)OC)N=C2C1C=CC(Cl)=CC=1

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ALW-II-41-27 - CAS# 1186206-79-0 Catalog No.:M10038-10 CC1C2=C(SC=1C(=O)NCCCCCNC1=CC=CC3=C1C(=O)N(C1CCC(=O)NC1=O)C3=O)N1C(=NN=C1C)[C@H](CC(=O)OC)N=C2C1C=CC(Cl)=CC=1ALW II 41 27 is a Eph receptor tyrosine kinase inhibitor. pharmacologic inhibition of EPHA2 by the small molecule inhibitor ALW II 41 27 decreased both survival and proliferation of erlotinib resistant tumor cells and inhibited tumor growth in vivo. ALW II 41 27 was also effective in decreasing viability of cells with acquired resistance to the third generation EGFR TKI AZD9291. Collectively, these data define a role for EPHA2 in the maintenance of

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CC1C2=C(SC=1C(=O)NCCCCCNC1=CC=CC3=C1C(=O)N(C1CCC(=O)NC1=O)C3=O)N1C(=NN=C1C)[C@H](CC(=O)OC)N=C2C1C=CC(Cl)=CC=1

InChiKey: YIXMZTZPXFTXTJ-UHFFFAOYSA-N

Administration of CHR-2797 (~100 mg/kg) decreases tumor volumes in vivo

Formula: C24H16O7

This mechanism of action is unique among antiepileptic drugs

ALW-II-41-27 - CAS# 1186206-79-0 Catalog No.:M10038-10 CC1C2=C(SC=1C(=O)NCCCCCNC1=CC=CC3=C1C(=O)N(C1CCC(=O)NC1=O)C3=O)N1C(=NN=C1C)[C@H](CC(=O)OC)N=C2C1C=CC(Cl)=CC=1ALW II 41 27 is a Eph receptor tyrosine kinase inhibitor. pharmacologic inhibition of EPHA2 by the small molecule inhibitor ALW II 41 27 decreased both survival and proliferation of erlotinib resistant tumor cells and inhibited tumor growth in vivo. ALW II 41 27 was also effective in decreasing viability of cells with acquired resistance to the third generation EGFR TKI AZD9291. Collectively, these data define a role for EPHA2 in the maintenance of

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