ADC Toxin Monomethyl auristatin F (MMAF) - CAS# 745017-94-1 Catalog No.:T60002-10S Molecular Weight: 247

Molecular Weight: 247

Formula: C18H17ClN2O3S

It induces a G2/M cell cycle arrest by interfering with the normal development of the mitotic spindle and causing collapsed spindle apparatus and multiple nucleation centres

activates human GPR84 in the presence of Gqi5 chimera in HEK293 cells with an EC50 of 105 nM in the PI assay

2006 Jan-Feb

ADC Toxin Monomethyl auristatin F (MMAF) - CAS# 745017-94-1 Catalog No.:T60002-10S Molecular Weight: 247MMAF (Monomethylauristatin F) , CAS No. 745017 94 1, is a potent tubulin polymerization inhibitor and is used as a antitumor agent. MMAF (Monomethylauristatin F) is widely used as a cytotoxic component of antibody drug conjugates (ADCs) such as vorsetuzumab mafodotin and SGN CD19A. Product information CAS Number: 745017 94 1 Molecular Weight: 731. 96 Formula: C39H65N5O8 Chemical Name: (S) 2 ((2R,3R) 3 ((S) 1 ((3R,4S,5S) 4 ((S) N,3 dimethyl 2 ((S) 3