Tanshinone I Size:2mg solid A single-dose administration to rats

A single-dose administration to rats the LD50 is >2000 mg/kg bwt by the oral route

2239273-34-6

Pharmaceut Med

inhibition of Aurora kinase activity by ZM-447439 results in abnormalities during mitosis by regulating the phosphorylation of histone H3 serine 10 (H3S10Ph) from G2 to metaphase with different perturbations in each embryonic cycle

Rosiglitazone-mediated PPARγ stimulation promotes adipocyte differentiation

Tanshinone I Size:2mg solid A single-dose administration to ratsTanshinone I is a diterpene with anticancer, antidiabetic, and neuroprotective properties. It inhibits proliferation in a variety of cancer cell lines, including KB VCR, MCF 7 ADR, and K562 A02 multidrug resistance cell lines. It inhibits topoisomerase I and topoisomerase II mediated supercoiled DNA relaxation activity and inhibits proliferation of H358 IR and H157 IR radioresistant lung cancer cells. It reduces plasma levels of total cholesterol,