NF-κB2 p100(Phospho-Ser866/870) Rabbit Polyclonal Antibody, 50ul Drug Development and Evaluation Mutations in SLC22A18 have been

Mutations in SLC22A18 have been found in Wilms' tumor and lung cancer

By sequence homology

and overexpression of this gene in primary tumors is linked to the repression of let-7 family of microRNAs and derepression of let-7 targets

The hepatocyte growth factor activator is first synthesized as an inactive single-chain precursor before being activated to a heterodimeric form by endoproteolytic processing

This gene belongs to the G-protein-coupled receptor superfamily

NF-κB2 p100(Phospho-Ser866/870) Rabbit Polyclonal Antibody, 50ul Drug Development and Evaluation Mutations in SLC22A18 have beenThis gene encodes a subunit of the transcription factor complex nuclear factor kappa B (NFkB). The NFkB complex is expressed in numerous cell types and functions as a central activator of genes involved in inflammation and immune function. The protein encoded by this gene can function as both a transcriptional activator or repressor depending on its dimerization partner. The p100 full length protein is co translationally processed into a p52 active