Rat Insulin-like Growth Factors 1 Receptor, IGF-1R ELISA Kit, 96T DNA Fragments EBI3 was identified by its

EBI3 was identified by its induced expression in B lymphocytes in response Epstein-Barr virus infection

Mutations in this gene are associated with several congenital cardiovascular malformations

further cleavages takes place in the heavy chain

Bone morphogenetic protein 3 suppresses osteoblast differentiation

It is also involved in oogenesis and in neuronal differentiation

Rat Insulin-like Growth Factors 1 Receptor, IGF-1R ELISA Kit, 96T DNA Fragments EBI3 was identified by itsReceptor tyrosine kinase which mediates actions of Insulin like growth factor 1 (IGF1). Binds IGF1 with high affinity and IGF2 and insulin (INS) with a lower affinity. The activated IGF1R is involved in cell growth and survival control. IGF1R is crucial for tumor transformation and survival of malignant cell. Ligand binding activates the receptor kinase, leading to receptor autophosphorylation, and tyrosines phosphorylation of multiple substrates,