MLH3 Polyclonal Antibody, 50ul Modified Oligos The encoded protein is a

The encoded protein is a class 3 semaphorin receptor| and may be involved in cytoskeletal remodeling and as well as apoptosis

This protein preferentially binds to the SH3 domain of c-Abl kinase

It also binds to activators and other transcriptional regulators

Contains 1 HECT (E6AP-type E3 ubiquitin-protein ligase) domain

in which it interacts directly with SKP1

MLH3 Polyclonal Antibody, 50ul Modified Oligos The encoded protein is aMLH3 is a member of the MutL homolog (MLH) family of DNA mismatch repair (MMR) genes. MLH genes are implicated in maintaining genomic integrity during DNA replication and after meiotic recombination. The mutL homolog 3 encoded by MLH3 functions as a heterodimer with other family members. Somatic mutations in this gene frequently occur in tumors exhibiting microsatellite instability, and germline mutations have been linked to hereditary nonpolyposis