Pirh2 Monoclonal Antibody, 100ul Pathway and Network Analysis The precise role of this

The precise role of this protein is unknown but studies suggest it may play a role in cytoskeletal organization| vesicular transport| or in transcriptional regulation of both nuclear and mitochondrial genes

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but shuttles into the nucleus where it localizes to nuclear speckles

Pirh2 Monoclonal Antibody, 100ul Pathway and Network Analysis The precise role of thisThe protein encoded by this gene has ubiquitin ligase activity. It mediates E3 dependent ubiquitination and proteasomal degradation of target proteins, including tumor protein 53, histone deacetylase 1, and cyclin dependent kinase inhibitor 1B, thus regulating their levels and cell cycle progression. Alternatively spliced transcript variants encoding different isoforms have been described for this gene.