SMAD7 Polyclonal Antibody, 100ul Diagnostic Probes & Oligos Mutations in this gene have

Mutations in this gene have been associated with several diseases

The activity of eukaryotic elongation factor 2 kinase is increased in many cancers and may be a valid target for anti-cancer treatment

Studies in other mammals suggest this protein plays a role in cell adhesion

Mannose receptor C type 2 plays a role in extracellular matrix remodeling by mediating the internalization and lysosomal degradation of collagen ligands

The product of this gene typically dimerizes with keratin 18 to form an intermediate filament in simple single-layered epithelial cells

SMAD7 Polyclonal Antibody, 100ul Diagnostic Probes & Oligos Mutations in this gene haveThe protein encoded by this gene is a nuclear protein that binds the E3 ubiquitin ligase SMURF2. Upon binding, this complex translocates to the cytoplasm, where it interacts with TGF beta receptor type 1 (TGFBR1), leading to the degradation of both the encoded protein and TGFBR1. Expression of this gene is induced by TGFBR1. Variations in this gene are a cause of susceptibility to colorectal cancer type 3 (CRCS3). Several transcript variants encoding