PPR1A Polyclonal Antibody, 50ul Supplements The protein appears to bind

The protein appears to bind and regulate the promoters of the extracellular matrix genes MMP1

The encoded protein undergoes an initial autocatalytic processing event in the ER to generate a heterodimer which exits the ER and sorts to the trans-Golgi network where a second autocatalytic event takes place and the Catalytic activity is acquired

Detected at very low levels in healthy liver

but causes G2-M arrest in p53-null or –mutant cells

Substrates of the encoded protein include the transcription factor ATF2 and the microtubule dynamics regulator stathmin

PPR1A Polyclonal Antibody, 50ul Supplements The protein appears to bindInhibitor of protein phosphatase 1. This protein may be important in hormonal control of glycogen metabolism. Hormones that elevate intracellular cAMP increase I 1 activity in many tissues. I 1 activation may impose cAMP control over proteins that are not directly phosphorylated by PKA. Following a rise in intracellular calcium, I 1 is inactivated by calcineurin (or PP2B). Does not inhibit type 2 phosphatases.,PTM: Phosphorylation of Thr 35 is