Raf-1(Phospho Tyr341) Polyclonal Antibody, 50ul Custom DNA Oligos Mutations in this gene cause

Mutations in this gene cause abnormal migration of neurons during development and disrupt the layering of the cortex

but not to the corresponding alcohols

This gene has been found fused to a variety of translocation partner genes in various leukemias| most notably the t(9

This protein is involved in epithelial-mesenchymal transitions and has antiapoptotic activity

This encoded protein is known to associate with phytanoyl-CoA alpha-hydroxylase

Raf-1(Phospho Tyr341) Polyclonal Antibody, 50ul Custom DNA Oligos Mutations in this gene causeThis gene is the cellular homolog of viral raf gene (v raf). The encoded protein is a MAP kinase kinase kinase (MAP3K), which functions downstream of the Ras family of membrane associated GTPases to which it binds directly. Once activated, the cellular RAF1 protein can phosphorylate to activate the dual specificity protein kinases MEK1 and MEK2, which in turn phosphorylate to activate the serine threonine specific protein kinases, ERK1 and ERK2.