MDM2(Phospho Ser166) Polyclonal Antibody, 20ul Metabolic enzymes The estrogen receptor 1 localizes

The estrogen receptor 1 localizes to the nucleus where it may form a homodimer or a heterodimer with estrogen receptor 2

Isoform 1 is involved in UBTF-activated transcription

Some of these isoforms are beta subunits

This protein has been shown to be up-regulated in tumors| especially in breast tumors| and thus it is associated with tumor invasiveness

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MDM2(Phospho Ser166) Polyclonal Antibody, 20ul Metabolic enzymes The estrogen receptor 1 localizesThis gene encodes a nuclear localized E3 ubiquitin ligase. The encoded protein can promote tumor formation by targeting tumor suppressor proteins, such as p53, for proteasomal degradation. This gene is itself transcriptionally regulated by p53. Overexpression or amplification of this locus is detected in a variety of different cancers. There is a pseudogene for this gene on chromosome 2. Alternative splicing results in a multitude of transcript