TRAP220 Polyclonal Antibody, 50ul[BT-AP09180] Immunoassays Mutations in this gene cause

Mutations in this gene cause juvenile myoclonic epilepsy and childhood absence epilepsy type 4

where it is involved in transcriptional regulation

and are involved in stem cell development

autosomal dominant progressive external ophthalmoplegia-5

tissue specificity:Expressed in kidney

TRAP220 Polyclonal Antibody, 50ul[BT-AP09180] Immunoassays Mutations in this gene causeThe activation of gene transcription is a multistep process that is triggered by factors that recognize transcriptional enhancer sites in DNA. These factors work with co activators to direct transcriptional initiation by the RNA polymerase II apparatus. The protein encoded by MED1 (mediator complex subunit 1) is a subunit of the CRSP (cofactor required for SP1 activation) complex, which, along with TFIID, is required for efficient activation by SP1.